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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GRAPL All Species: 19.7
Human Site: S62 Identified Species: 36.11
UniProt: Q8TC17 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8TC17 NP_001123250 118 13442 S62 V K P H P W Y S G R I S R Q L
Chimpanzee Pan troglodytes XP_529824 164 17412 G62 V K P H P H L G P A L P R P S
Rhesus Macaque Macaca mulatta XP_001097817 217 25285 S62 V K P H P W Y S G R I S R Q L
Dog Lupus familis XP_546653 217 25309 S62 I K P H P W Y S G R I S R Q L
Cat Felis silvestris
Mouse Mus musculus Q9CX99 217 25259 S62 V K P H P W Y S G R I S R Q L
Rat Rattus norvegicus P62994 217 25188 F62 M K P H P W F F G K I P R A K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505772 217 25155 A62 L S P S P W Y A G R I S R Q L
Chicken Gallus gallus Q07883 217 25058 F62 M K P H P W F F G K I P R A K
Frog Xenopus laevis Q6GPJ9 229 26344 F62 M K P H P W F F G K I P R A K
Zebra Danio Brachydanio rerio NP_998200 217 25269 F62 M K A H P W F F G R I P R A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q08012 211 24417 Y62 M K N H D W Y Y G R I T R A D
Honey Bee Apis mellifera XP_623354 211 24679 Y62 M K N H D W Y Y G R I T R A D
Nematode Worm Caenorhab. elegans P29355 228 26192 L62 M T E C N W Y L G K I T R N D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 46.3 51.6 50.2 N.A. 49.3 35.4 N.A. 37.7 35.4 31.4 35.4 N.A. 29.8 30.8 28 N.A.
Protein Similarity: 100 51.2 52.5 52 N.A. 51.1 44.2 N.A. 45.1 43.7 41.9 43.7 N.A. 40.2 40.2 39.9 N.A.
P-Site Identity: 100 40 100 93.3 N.A. 100 53.3 N.A. 73.3 53.3 53.3 53.3 N.A. 53.3 53.3 33.3 N.A.
P-Site Similarity: 100 46.6 100 100 N.A. 100 73.3 N.A. 86.6 73.3 73.3 66.6 N.A. 66.6 66.6 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 8 0 8 0 0 0 47 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 24 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 31 31 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 93 0 0 0 0 0 0 % G
% His: 0 0 0 85 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 93 0 0 0 0 % I
% Lys: 0 85 0 0 0 0 0 0 0 31 0 0 0 0 24 % K
% Leu: 8 0 0 0 0 0 8 8 0 0 8 0 0 0 39 % L
% Met: 54 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 16 0 8 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 70 0 77 0 0 0 8 0 0 39 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 39 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 62 0 0 100 0 8 % R
% Ser: 0 8 0 8 0 0 0 31 0 0 0 39 0 0 8 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 24 0 0 0 % T
% Val: 31 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 93 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 62 16 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _